Challenge trials for a coronavirus vaccine are unethical – except for in one unlikely scenario
The world urgently needs a vaccine for COVID-19. Only when a vaccine is approved and people are safe can countries fully end their lockdowns and resume normal life. The trouble is that such vaccines usually take years to develop and test for efficacy and safety.
Recently, some bioethicists have proposed a way of speeding up this testing process by several months. Researchers would put volunteers in quarantine with access to the best medical care, give these volunteers one of the trial vaccines and then directly expose them to the coronavirus. This type of intentional exposure is called a challenge trial, and since researchers would not have to wait for subjects to encounter the virus in the normal course of their daily lives, it could result in a vaccine much faster than a normal trial. R...