immune

4Apr

By THEIRL1ADMIN01No Comments

HEALTH & WELLNESS

The Immune System Metabolism, And Genes Controlling Aging Can Be Influenced By Exposure To Man-Made Chemicals

Today humans are exposed to thousands of man-made chemicals. Yet the effects on people’s health are still not fully understood. In 2020 the number of registered chemicals reached 167 million. Every day people are exposed to them through food, water, contaminated air, drugs, cosmetics and other man-made substances. Less than 1% of these chemicals were tested for toxicity, and those that were tested demonstrate ability to disrupt almost every biological process in our body. Can we infer how cumulative exposures shape our health? I am an environmental toxicologist studying effects of man-made chemicals on our health. I decided to develop a computational approach to objectively compare sensitivity of all genes to all chemicals and identify the most vulnerable biological processes. Unbiased a...

CRISPR can help combat the troubling immune response against gene therapy

One of the major challenges facing gene therapy - a way to treat disease by replacing a patient’s defective genes with healthy ones - is that it is difficult to safely deliver therapeutic genes to patients without the immune system destroying the gene, and the vehicle carrying it, which can trigger life-threatening widespread inflammation. Three decades ago researchers thought that gene therapy would be the ultimate treatment for genetically inherited diseases like hemophilia, sickle cell anemia and genetic diseases of metabolism. But the technology couldn’t dodge the immune response. Since then, researchers have been looking for ways to perfect the technology and control immune responses to the gene or the vehicle. However, many of the strategies tested so far have not been completely s...

Older people are at more risk from COVID-19 because of how the immune system ages

The rapidly spreading coronavirus pandemic is taking a particularly harsh toll on older people. Data from the initial outbreak in China and then Italy show that infected people under the age of 60 are at low – but not no – risk of dying from COVID-19. Curiously, young children do not appear to be at increased risk of serious COVID-19 complications, in contrast to what happens with other viruses, like the seasonal flu. However, the statistics get grimmer as the patients get older. Whereas people in their 60s have a 0.4% chance of dying, people in their 70s have a 1.3% chance of dying, and people over 80 have a 3.6% chance of dying. While this may not sound like a high chance of death, during the current outbreak in Italy, 83% of those who succumbed to COVID-19 infection were over the age ...